Abstract:
Aim: The researchers intended to evaluate Activated Partial Thromboplastin Time (APTT) and Protein C (PC) amongst Sudanese
neonates with sepsis (Cases) in Omdurman maternity hospital, Sudan related with healthy neonates (controls) for recognizing
haemostatic alteration in APTT and PC amongst neonatal sepsis which cumulative yearly in Sub Saharan African countries along
with incessant home-grown efforts by governmental bodies and NGOs.
Results: An overall of 100 neonates alienated similarly into septic cases and healthy controls, died neonates were constituted 10
(20%) while 40 (80%) were recovered between case group.
APTT showed noteworthy continuation in septic neonates compared to controls (mean; 47.8 and 37.5 sec for cases and controls,
respectively) P-value was 0.00. Amongst patients group: dead neonates exhibited significant prolongation matched recovered (mean;
61.5 and 44.4 sec) P-value 0.00. PC showed noteworthy reduction in dead neonates compared to recovered (mean; 25.4 and 36.2%
for dead and improved). P-value 0.04.
Insignificant change in PC was found amid case and control group. None of the sex, gestational age, delivery method, sepsis onset,
and causative agent displayed noteworthy correlation with APTT and PC. APTT&PC can be valuable as indicator of neonatal sepsis
mortality.
Conclusion: APTT was meaningfully prolonged in neonatal sepsis (P-value 0.00). APTT also prolonged considerably in deceased
septic neonates matched to recovered one (P-value 0.00). PC reduced expressively in dead neonates compared to recover in case
group (P-value 0.04). Prolonged APTT and reduce PC can be valuable as a marker for neonatal sepsis mortality.
